squareThe molecular framework of chlordiazepoxide, the main benzodiazepine, marketed by Hoffmann–La Roche commencing in 1960 and branded as Librium The initial benzodiazepine, chlordiazepoxide (Librium), was synthesized in 1955 by Leo Sternbach when Doing work at Hoffmann–La Roche on the development of tranquilizers. The pharmacological Houses